Prof Matt Holden:
Prof Matt Holden
Medical and Biological Sciences Building
University of St Andrews
tel: 01334 463504
fax: 01334 463482
Holden Group Website
School of Medicine
Biomedical Sciences Research Complex
Evolution, Genes and Genomics Group
Institute for Data-Intensive Research
Medicine Infection Research Group
Holden Research Group
Task Force 3: Induction, Return to work
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Since the first bacterial genome was sequenced in 1995, whole genome sequencing (WGS) has provided unprecedented insights into the genetics and evolution of microbial pathogens. Having worked at the Sanger Institute 13 years on a broad range of bacterial genomes, I recently moved to the School of Medicine establishing a pathogenomics group. Research in my group is directed at two main areas: translational genomics, the application of WGS in clinical microbiology; and experimental genomics, using data WGS to investigate the relationship between pathogens’ genotypes and phenotypes.
The research areas that the group are focused on include: developing rapid WGS to combat hospital-associated infections, the molecular basis of antibiotic resistance and virulence, and epidemiology and evolution of methicillin resistant S. aureus (MRSA).
I started my research career with a PhD at Warwick University, studying the distribution and regulation of cryptic antibiotic genes in environmental and plant pathogenic bacteria. As a postdoc I then spent four years at the University of Nottingham, investigating bacterial communication. Initially working on the role of N-acyl homoserine lactones in quorum sensing in Pseudomonads, and then moving ‘languages’ to investigate peptide autoinducer-dependent regulation of virulence in Staphylococcus aureus. I then joined the The Wellcome Trust Sanger Institute in 2000, and have involved in the analysis of the genomes of a wide range of bacterial pathogens including Yersinia pestis, Salmonella typhi, Streptococcus pyogenes, Burkholderia pseudomallei, Burkholderia cenocepacia and S. aureus. With developments in next generation sequencing, the focus of my work has shifted towards populations studies, investigating genome diversity and pathogen evolution, as well as the application of sequencing in clinical microbiology. In 2013 I moved to the Medical School at University St Andrews to establish a research group focusing on experimental and translational pathogen genomics.
My research interest include: the survival and evolution of MRSA, and probing the link between a pathogen’s genotype and virulence, and also the application of genomics in clinical setting to combat hospital-associated infections.
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Recent Publications:5 (of 156 /dk/atira/pure/researchoutput/status/published available) for mtgh (source: University of St Andrews PURE)
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Scientific Reports 2020 vol. 10
Microbiology Resource Announcements 2020 vol. 9
Microbial Genomics 2020 vol. 6
Annals of Allergy Asthma & Immunology 2019 vol. 122 pp. 236-240
Nature Genetics 2019 vol. 51 pp. 1035-1043